Emphysema is a chronic lung condition in which the air sacs (alveoli) may be:
Overinflation of the air sacs is a result of a breakdown of the alveoli walls. It causes a decrease in respiratory function and breathlessness. Damage to the air sacs can't be fixed. It causes permanent breakdown in the lower lung tissue.
Pulmonary emphysema is part of a group of lung diseases called COPD (chronic obstructive pulmonary disease). COPD causes airflow blockage and breathing problems. The 2 most common conditions of COPD are chronic bronchitis and emphysema.
Pulmonary emphysema can be caused by several factors, with smoking being the main risk factor. The different causes lead to different parts of the lungs being affected.
Centrilobular pulmonary emphysema affects the upper part of the lung. It is believed that pollutants, such as cigarette smoke or other chemical substances, initially reach and damage the upper tissues of the lungs.
If the lower lung sections are affected in particular, this indicates a congenital defect of certain enzymes, leading to panlobular pulmonary emphysema. After lung surgery, during which parts of the lungs are removed, the residual lung may expand excessively. This leads to distension emphysema.
Symptoms may be slightly different for each person. These are the most common:
Along with a complete health history and physical exam, your healthcare provider may do pulmonary function tests. These tests help measure the lungs’ ability to exchange oxygen and carbon dioxide. The tests are often done with special machines into which you breathe. They may include:
A spirometer is a device used to check lung function. Spirometry is one of the simplest, most common tests. It may be used to:
This device measures how fast you can blow air out of your lungs. Cough, inflammation, and mucus buildup can cause the large airways in the lungs to slowly narrow. This slows the speed of air leaving the lungs. This measurement is very important in seeing how well or how poorly the disease is being controlled.
These are done to check the amount of carbon dioxide and oxygen in the blood. A blood test may be done to check eosinophil counts and vitamin D levels, and to monitor your hematocrit and hemoglobin levels for anemia.
This test takes pictures of internal tissues, bones, and organs. A chest X-ray is not recommended to diagnose COPD, but it can help identify other conditions.
This test uses a combination of X-rays and computer technology to make images of the body. A CT scan can show details such as the width of airways in the lungs and the thickness of airway walls.
This test is done on the material that is coughed up from the lungs and into the mouth. A sputum culture is often used to see if an infection is present. It may also be done to check eosinophil levels. It generally takes 2 days to get the results.
This is a test that records the electrical activity of the heart, shows abnormal rhythms (arrhythmias), and can help find heart muscle damage.
FEV-1 less than 40 percent of predicted value, or; the ratio of Forced Expiratory Volume in one second to Forced Vital Capacity (FEV-1/FVC) less than 40 percent, or; Diffusion Capacity of the Lung for Carbon Monoxide by the Single Breath Method (DLCO (SB)) less than 40-percent predicted, or; maximum exercise capacity less than 15 ml/kg/min oxygen consumption (with cardiac or respiratory limitation), or; cor pulmonale (right heart failure), or; right ventricular hypertrophy, or; pulmonary hypertension (shown by Echo or cardiac catheterization), or; episode(s) of acute respiratory failure, or; requires outpatient oxygen therapy.
FEV-1 of 40- to 55-percent predicted, or; FEV-1/FVC of 40 to 55 percent, or; DLCO (SB) of 40- to 55-percent predicted, or; maximum oxygen consumption of 15 to 20 ml/kg/min (with cardiorespiratory limit)
FEV-1 of 56- to 70-percent predicted, or; FEV-1/FVC of 56 to 70 percent, or; DLCO (SB) 56- to 65-percent predicted
FEV-1 of 71- to 80-percent predicted, or; FEV-1/FVC of 71 to 80 percent, or; DLCO (SB) 66- to 80-percent predicted
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